With a stay at Hotel Misional in Santa Cruz, you'll be just steps from Sacred Art Museum and Casa Municipal de Cultura Raúl Otero Reiche. This hotel is 0.2 mi (0.3 km) from Centro Cultural Feliciana Rodríguez and 0.3 mi (0.4 km) from Guarani Nandereko Nomai Art and Culture Center.

Make yourself at home in one of the 32 air-conditioned rooms featuring minibars and flat-screen televisions. Complimentary wired internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers. Conveniences include phones, as well as safes and desks.

This hotel offers designated smoking areas.

Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers 24-hour room service. Wrap up your day with a drink at the bar/lounge. A complimentary buffet breakfast is served daily from 7 AM to 9:30 AM.

Featured amenities include a computer station, dry cleaning/laundry services, and a 24-hour front desk. A roundtrip airport shuttle is provided for a surcharge (available 24 hours), and free self parking is available onsite.